Table 3.
SNP ID | Chr 6 position | Gene | Class | MAF | Allele | Haplotype block numberb |
Relation to VL |
---|---|---|---|---|---|---|---|
1st Analysisc | |||||||
rs3823376 | 30,052,163 | HCG9 | ncRNA | 0.404 | G | NA | Low |
rs2517425 | 31,057,649 | MUC21 | intergenic | 0.280 | C | 170 | Low |
rs2857114 | 32,887,974 | HLA-DQB2|HLA-DOB | downstream | 0.457 | C | 346 | High |
2nd analysisd | |||||||
rs2857114 | 32,887,974 | HLA-DQB2|HLA-DOB | downstream | 0.457 | C | 346 | High |
Testing additive effects for the minor alleles of single nucleotide polymorphisms (SNPs); MAF, minor allele frequency.
Not all eligible SNPs can be assigned to haplotype blocks (details are shown in Supplemental Materials). NA, not applicable.
First analysis has adjusted for sex and age at VL measurement; overall R2=14.8% for the model.
Second analysis has adjusted for sex, age at VL measurement, HLA-A*36, A*74, B*57, B*81 and DRB1*01:02; Overall R2=14.9% for the model.