Figure 6.

Phenotypes 2 and 3: Decreased waveguiding and disrupted photoreceptor mosaic. Drusen were present in four subjects in which the overlying photoreceptor mosaic was undisturbed, consistent with previous observations.¹¹ Interestingly, the photoreceptors on the edge of these drusen had diminished reflectivity. This is most likely due to the Stiles-Crawford effect; where the three dimensional druse alters the trajectory of the reflected light. (A) AOSLO image from subject JC_0803, displaying decreased waveguiding phenotype. (B) Logarithmic view of AOSLO image. Scale bar = 50 µm. (C) Corresponding OCT, with region imaged with AOSLO marked with vertical black arrow. In three subjects, drusen were present and the overlying photoreceptor mosaic was disturbed. By viewing on a logarithmic scale, it is evident that the photoreceptors are no longer discernable on the edge of drusen. These photoreceptor changes were not detected on SD-OCT. (D) AOSLO image from subject JC_1018, displaying disrupted photoreceptor mosaic. (E) Logarithmic view of AOSLO image. Scale bar = 50µm. (F) Corresponding SD-OCT, with region imaged with AOSLO marked with vertical white arrow.