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Changes from baseline in heart rate (HR), systolic blood pressure (SBP), & diastolic blood pressure (DBP) in poor (PM), intermediate (IM), extensive (EM) and ultrarapid (UM) metabolizers of CYP2D6 treated with metoprolol
| Parameter | PM | IM | EM | UM | P |
|---|---|---|---|---|---|
|
| |||||
| Change in HR (beats/min) | −16.6± 6.9 | − 18.6± 5.1 | −11.4± 6.6 | −11.2± 8.2 | 0.0001 |
| Change in SBP (mm Hg) | −9.4± 9.0 | −6.5± 11.1 | −7.1± 9.8 | −9.4± 5.1 | 0.91 |
| Change in DBP (mm Hg) | −9.3± 5.1 | −8.3± 7.5 | −7.0± 6.6 | −7.5± 4.8 | 0.37 |
