Table 4.

Results of Analysis of Covariance (ANCOVA) test showing CYP2D6 phenotype as a significant predictor of variability in heart rate changes only with metoprolol.

Variable	Heart rate				Systolic blood pressure				Diastolic blood pressure
	beta	SE*	95% CI **	p	beta	SE*	95% CI**	p	beta	SE*	95% CI **	p
CYP2D6 phenotype (PM)	2.10	0.70	0.73,3.47	0.004	− 0.03	1.6	−3.17,3.11	0.97	0.50	0.7	−2.8,3.8	0.50
Baseline heart rate (bpm)	− 0.34	0.04	−0.42, −0.26	< 0.0001
Baseline SBP (mm Hg)					− 0.17	0.06	−0.30, −0.05	0.003
Baseline DBP (mm Hg)									− 0.21	0.07	−0.35, −0.07	0.0026
Age (years)	− 0.16	0.04	−0.08, −0.24	0.0002	0.04	0.07	−0.10,0.18	0.52	− 0.01	0.04	−0.09,0.07	0.74
Race (African American)	− 2.24	0.80	−0.67, −3.8	0.007	− 6.61	1.30	−9.16, −4.06	< 0.0001	− 5.01	0.86	−3.33, −7.70	< 0.0001
Gender (Female)	0.55	0.80	−1.02,2.12	0.49	4.57	1.25	2.12,7.02	0.0003	3.48	0.82	1.88,5.36	< 0.0001

^*SE: standard error,

^**CI: confidence interval