Table 1.
Clinical Characteristics of Pulmonary tuberculosis Study Populations From the Moroccan Family-based and Case-control Studies
| Characteristic | Family-Based (Part 1) |
Family-Based (Part 2) |
Case-Control |
Combined |
|||
|---|---|---|---|---|---|---|---|
| Founders | Offspring | Founders | Offspring | Cases | Controlsa | Affected Offspring and Cases | |
| N | 151 | 194 | 138 | 156 | 300 | 624 | 560 |
| N by status (affected; unaffected/ unknown) | 39; 112 | 141; 53 | 31; 107 | 119; 37 | … | … | … |
| Age in years: mean (SD, range) by status | |||||||
| Affected | 44 (13.3, 16–70) | 22.2 (8.5, 2–51) | 48.5 (12.1, 21–66) | 20.7 (7.4, 1–42) | 29.9 (10.6, 8–69) | … | 26 (10.4, 1–69) |
| Unaffected/Unknown | 52 (9, 30–73) | 27.2 (10.1, 10–50) | 49.9 (10.4, 24–73) | 24.4 (5.3, 18–39) | … | 32.5 (8.9, 20–68) | … |
| % Males by status | |||||||
| Affected | 61.5 | 56.7 | 51.6 | 48.7 | 75 | … | 64.8 |
| Unaffected/Unknown | 39.2 | 41.5 | 42.1 | 43.2 | … | 62.5 | … |
a Controls were recruited from among healthy blood donors. Although we cannot exclude the possibility that some of these controls may develop pulmonary tuberculosis later in life (in any case no more than 5%, the expected proportion of infected individuals who develop pulmonary tuberculosis after infection by Mycobacterium tuberculosis), the level of misclassification should be quasi-negligible ( <5%) as the control population is older than the cases and do not have a history of tuberculosis. In any case, this slight possible misclassification of controls can only affect the power of our analysis and could not lead to false positive results.