Table 5.
SNP | ma | Ma | Freq (Risk)b | Modelc | Family and Case Control |
<25 y |
≥25 y |
|||
---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI)d | P Valued | OR (95% CI)d | P Valued | OR (95% CI)d | P Valued | |||||
rs1031509 | A | C | 0.59 | REC | 1.27 (1.01–1.61) | .045 | 1.47 (1.1–2) | .011 | 1.06 (.78–1.45) | .70 |
rs7572482 | G | A | 0.48 | REC | 1.32 (1.03–1.70) | .030 | 1.49 (1.08–2.07) | .016 | 1.19 (.86–1.65) | .30 |
rs897200 | G | A | 0.48 | REC | 1.35 (1.05–1.74) | .019 | 1.47 (1.06–2.04) | .019 | 1.28 (.92–1.78) | .15 |
Abbreviations: CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism.
a Minor (m) and Major (M) allele; the risk allele is underlined.
b Risk allele frequency.
c Genetic model (REC, recessive).
d Odds ratio (95% confidence interval) and P-value for the 2-sided Wald test in reference to the risk allele from combined analysis using the conditional logistic regression framework.