Table 2.

Top SNPs associated with D-dimer in European Americans and replication in the other ethnic groups

Counts	rs6025 (FV Leiden)	rs13109457^*	rs6050
Region	1q23	4q28	4q28
Genes/Function	FV/coding-nonsynonymous (Arg506Gln)	~3kb from FGA/intergenic	FGA/coding-nonsynonymous (Thr331Ala)
A1/A2^†	A/G	A/G	A/G
*European Americans*
N	6625	6710	6848
Allele A1 Frequency	0.026	0.254	0.761
Beta (Beta_raw)^‡	0.459 (114.25)	0.102 (11.31)	−0.100 (−7.89)
P-value	7.41×10⁻¹⁶	7.52×10⁻⁷	1.24×10⁻⁶
*African Americans*
N	− ^§	2192	2194
Allele A1 Frequency	-	0.256	0.641
Beta (Beta_raw)	-	0.035 (17.56)	−0.093 (−34.13)
P-value	-	0.329	0.006
*Asians*
N	-	670	670
Allele A1 Frequency	-	0.439	0.553
Beta (Beta_raw)		0.053 (29.23)	−0.053 (−29.01)
P-value	-	0.361	0.367
*Hispanics*
N	1286	1286	1286
Allele A1 Frequency	0.013	0.252	0.732
Beta (Beta_raw)	0.401 (43.65)	0.041 (1.40)	−0.057 (−7.87)
P-value	0.023	0.377	0.221

CHS indicates Cardiovascular Health Study, CFS, Cleveland Family Study; FHS, Framingham Heart Study; MESA, Multi-Ethnic Study of Atherosclerosis.

r² between rs13109457 and rs6050 in EA, AA, and Asian are 0.91, 0.47, and 1.00, respectively, r² is not available in Hispanics;

^†

A1: coded allele, A2=non-coded allele;

^‡

Beta: regression coefficient refers to the change in inverse normal transformed residuals of D-dimer level per 1-allele increase in the A1 allele for each race group; Beta_raw: regression coefficient refers to the change in raw D-dimer level (i.e., untransformed, ng/mL) per 1-allele increase in the A1 allele for each race group

^§

Very rare or monomorphic.