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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2014 Jun 2;0:366–382. doi: 10.1016/j.freeradbiomed.2014.05.015

Fig. 5.

Fig. 5

Body weight and longevity extension by caloric restriction in the female C57BL/6 ob/ob congenic and normal mice (re-plotted from [87]). The shaded area represents the cumulative weight gain under AL feeding starting at 1 months of age until the peak body weight was reached. Median age of survival under AL and CR conditions is shown, respectively, as solid and dotted vertical lines along the x-axis. The grey area in between these two lines represents the increase in longevity resulting from CR. Note that increases in body weight under AL feeding as well as the CR-related increase in longevity were much greater in the ob/ob than in the normal mice. This pattern is similar to that shown in Figures 2–4.