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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: J Heart Lung Transplant. 2014 Mar 5;33(8):785–793. doi: 10.1016/j.healun.2014.02.030

Figure 1.

Figure 1

Recapitulation of the fetal gene program (FGP) occurs in the hypoplastic left heart syndrome (HLHS) right ventricle (RV). Messenger (m)RNA expression was determined in tissue from non-failing RV (NF-RV) controls (n = 11) and in RV tissue from compensated (C)-HLHS (n = 8) and decompensated (D)-HLHS patients (n = 11). There was a pathologic gene expression pattern in HLHS with increased expression of (A) atrial natriuretic peptide (ANP) in C-HLHS and (B) β-myosin heavy chain (MHC) in D-HLHS, along with decreased expression of (C) sarcoplasmic reticulum calcium-adenosine triphosphatase (SERCA) and (D) α-MHC in both HLHS groups compared with NF-RV. (E) B-type natriuretic peptide (BNP) was unchanged in HLHS compared with NF-RV. Results are presented as the mean with the standard error (error bars).