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. 2014 Mar 19;18(6):1194–1202. doi: 10.1111/jcmm.12265

Figure 4.

Figure 4

Intravenous injection of Gr-1+CD11b+ myeloid cells improved blood flow recovery and capillary density in the ischaemic limb of diabetic mice. (A) Representative laser Doppler imaging of blood flow recovery of ischaemic limb; left panel, ischaemic limb immediately after hindlimb ischaemia; right panel, ischaemic limb after 21 days of hindlimb ischaemia; upper panel, ischaemic limb from mice intravenously injected with saline; lower panel, ischaemic limb from mice intravenously injected with Gr-1+CD11b+ myeloid cells. (B) Gr-1+CD11b+ myeloid cells significantly improved blood flow recovery of the ischaemic limb compared with the saline control, *P < 0.01, n = 5 in each group. (C) Representative photographs of immunostaining of CD31 in the ischaemic limb muscle. (a) isotype control of ischaemic limb of mice; (b) ischaemic limb from mice intravenously injected with saline; (c) ischaemic limb from mice intravenously injected with Gr-1+CD11b+ myeloid cells. Magnification ×200 for each image. (D) Gr-1+CD11b+ myeloid cells significantly increased capillary density of the ischaemic limb, *P < 0.01 versus saline, n = 5 in each group.