Table 1.
Subject Characteristics
| Characteristic | Controls (n = 32) | COPD (n = 61) | p value |
|---|---|---|---|
| Age, years | 58 ± 12 | 62 ± 9 | .146 |
| Gender, % female | 57 | 46 | .465 |
| Former Smoker, % | 68 | 79 | .909 |
| Current Smoker, % | 32 | 21 | .909 |
| Cigarette pack-years | 36 ± 22 | 45 ± 16 | .411 |
| Statin use, % | 24 | 37 | .280 |
| Peripheral Blood | |||
| Monocytes/μl | 204 ± 113 | 281 ± 176 | .139 |
| Lymphocytes/μl | 1137 ± 543 | 1100 ± 457 | .790 |
| Pulmonary Function | |||
| FEV1 - Pre albuterol, % pred | 90 ± 11 | 41 ± 18 | <.0001 |
| FEV1 - Post | 96 ± 11 | 46 ± 18 | <.0001 |
| FVC - Pre albuterol, % pred | 91 ± 13 | 68 ± 20 | <.0001 |
| FVC - Post | 96 ± 12 | 75 ± 17 | <.0001 |
| FEV1/FVC, % | 79 ± 7 | 51 ± 15 | <.0001 |
| GOLD Stage, n (% of group) | |||
| I, Mild | 3 (5%) | ||
| II, Moderate | 27 (44%) | ||
| III, Severe | 22 (36%) | ||
| IV, Very Severe | 9 (15%) | ||
| High Resolution CT | (n = 29) | (n = 60) | |
| % with emphysema | 31 | 82 | <.0001 |
| % with coronary calcification | 30 | 58 | .044 |
FEV1 = Forced expiratory volume 1 second; FVC = forced vital capacity; CT = computed tomography.
Values are shown as mean, SD.