Table 2. Association signals for risk loci significantly associated with the combined coronary artery disease/ stroke phenotypes in meta-analyses.
shown are loci with p<5e-8. SNPs showing the lowest meta-p-values in the respective region are reported. Data were drawn from METASTROKE and CARDIoGRAM. Results are shown for both IS and LAS
| rs_number | Band | Gene in region | CAD p-value | IS p-value | Effects go in the same direction | CAD & IS combined p-value | FDR q-value |
|---|---|---|---|---|---|---|---|
| Ischemic Stroke | |||||||
|
| |||||||
| rs1333049 | 9p21.3 | CDKN2BAS | 2.96E-56 | 0.005 | yes | 1.09E-56 | 5.00E-51 |
| rs11065987 | 12q24.12 | chr12q24/SH2B3 | 5.13E-09 | 1.62E-07 | yes | 4.05E-14 | 9.60E-10 |
| rs10455872 | 6q25.3 | SLC22A3/LPAL2/LPA | 3.15E-13 | 0.322 | yes | 1.72E-12 | 3.75E-08 |
| rs1122608 | 19p13.2 | LDLR/SMARCA4 | 3.32E-11 | 0.002 | yes | 2.59E-12 | 5.52E-08 |
| rs4714955 | 6p24.1 | PHACTR1 | 6.30E-12 | 0.498 | no | 4.24E-11 | 8.30E-07 |
| rs11556924 | 7q32.2 | ZC3HC1 | 2.55E-10 | 0.217 | yes | 9.37E-10 | 1.59E-05 |
| rs964184 | 11q23.3 | ZNF259 | 1.50E-10 | 0.871 | yes | 1.17E-09 | 1.95E-05 |
| rs579459 | 9q34.2 | ABO | 2.14E-07 | 0.0003 | yes | 1.81E-09 | 2.95E-05 |
| rs2219939 | 15q25.1 | ADAMTS7 | 2.65E-09 | 0.042 | no | 2.49E-09 | 3.97E-05 |
| rs7582720 | 2q33.1 | WDR12 | 3.76E-09 | 0.052 | no | 4.18E-09 | 6.30E-05 |
| rs599839 | 1p13.3 | SORT1 | 1.41E-09 | 0.938 | yes | 1.07E-08 | 0.00014 |
| rs12190287 | 6q23.2 | TCF21 | 2.32E-09 | 0.823 | no | 1.69E-08 | 0.00022 |
| rs12449964 | 17p11.2 | RAI1-PEMT-RASD1 | 1.64E-07 | 0.005 | yes | 2.23E-08 | 0.00028 |
| rs17114036 | 1p32.2 | PPAP2B | 9.78E-09 | 0.162 | yes | 2.66E-08 | 0.00032 |
| rs9351814 | 6q13 | C6orf155 | 1.45E-07 | 0.015 | yes | 4.93E-08 | 0.00055 |
|
| |||||||
| Large Artery Stroke | |||||||
|
| |||||||
| rs1333049 | 9p21.3 | CDKN2BAS | 2.96E-56 | 3.85E-06 | yes | 1.20E-59 | 5.92E-54 |
| rs10455872 | 6q25.3 | SLC22A3/LPAL2/LPA | 3.15E-13 | 0.009 | yes | 9.25E-14 | 2.18E-09 |
| rs2107595 | 7p21.1 | HDAC9 | 0.042 | 2.39E-12 | yes | 2.60E-12 | 5.72E-08 |
| rs1122608 | 19p13.2 | LDLR/SMARCA4 | 3.32E-11 | 0.017 | yes | 1.56E-11 | 3.31E-07 |
| rs4714955 | 6p24.1 | PHACTR1 | 6.30E-12 | 0.173 | no | 2.11E-11 | 4.42E-07 |
| rs12936587 | 17p11.2 | RAI1-PEMT-RASD1 | 1.98E-07 | 2.69E-05 | yes | 1.93E-10 | 3.56E-06 |
| rs11065987 | 12q24.12 | chr12q24/SH2B3 | 5.13E-09 | 0.002 | yes | 3.20E-10 | 5.77E-06 |
| rs11556924 | 7q32.2 | ZC3HC1 | 2.55E-10 | 0.167 | yes | 7.74E-10 | 1.33E-05 |
| rs599839 | 1p13.3 | SORT1 | 1.41E-09 | 0.023 | yes | 8.17E-10 | 1.40E-05 |
| rs964184 | 11q23.3 | ZNF259 | 1.50E-10 | 0.468 | no | 9.14E-10 | 1.55E-05 |
| rs12190287 | 6q23.2 | TCF21 | 2.32E-09 | 0.814 | yes | 1.69E-08 | 0.00023 |
| rs12413409 | 10q24.32 | CYP17A1-CNNM2-NT5C2 | 1.24E-06 | 0.0005 | yes | 1.77E-08 | 0.00023 |
| rs6841581 | 4q32.21 | EDNRA | 8.45E-07 | 0.0007 | yes | 1.78E-08 | 0.00024 |
| rs17114036 | 1p32.2 | PPAP2B | 9.78E-09 | 0.133 | yes | 2.29E-08 | 0.00029 |
| rs899997 | 15q25.1 | ADAMTS7 | 4.75E-09 | 0.391 | no | 2.41E-08 | 0.00030 |
| rs7582720 | 2q33.1 | WDR12 | 3.76E-09 | 0.682 | no | 2.55E-08 | 0.00032 |
| rs579459 | 9q34.2 | ABO | 2.14E-07 | 0.005 | yes | 2.96E-08 | 0.00036 |
In bold: p-value for the combined phenotype is more than one order of magnitude lower than in individual meta-analyses on the individual phenotypes. Note that variants at individual loci may differ from those reported in Table 1