Table 4.

^* Accumulation of amyloid at 2 weeks or 6 weeks post-AEF in mice treated with clodronate liposomes.

Congo red quantitation (0–4)
	2 wk post AEF			6 wk post AEF
	Clodronate	Control	t-test	Clodronate	Control	t-test
Liver	0.24 ± 0.29	1.13 ± 0.77	p = 0.007	2.1 ± 0.22	2.6 ± 0.25	p=0.013
Spleen	0.38 ± 0.59	1.43 ± 0.88	p = 0.006	2.5 ± 0.35	3.0 ± 0.0	p = 0.027
125I-p5R autoradiograph scoring (0–4)
Liver	0.59 ± 0.49	1.61 ± 0.98	p = 0.16	3.2 ± 0.27	3.5±0.0	p=0.074
Spleen	0.53 ± 0.43	1.77 ± 0.78	p = 0.002	1.75 ± 0.66	1.62 ± 0.25	p = 0.73

^*huIL-6 mice were injected with 10μg AEF and treated with clodronate liposomes (day 5) or not treated. After 2 weeks, mice were injected iv with ¹²⁵I p5R and tissues were harvested 2 h later. Tissues were scored for Congo red stain or for ¹²⁵I p5R autoradiography. Tissues were also evaluated for biodistribution (see figure 6). Values are 0–4⁺ scoring ± standard deviation. N=10 for 2 week and n=5 for 6 week groups.