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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Trends Cell Biol. 2014 Apr 29;24(8):464–471. doi: 10.1016/j.tcb.2014.04.002

Figure 1.

Figure 1

Various uses of NAD+ for canonical redox and NAD+-consuming enzymatic reactions. Whereas NAD+ is converted to NADH by many metabolic enzymes (a), it is also used as a cosubstrate for NAD+-consuming enzymes, such as poly-ADP-ribose polymerases (PARPs) (b), sirtuins (c), and CD38/157 ectoenzymes (d).