Table 3.
N | NRM at Day 100
|
P-Value | Risk of Cardiac Complications
|
95% CI | P- Value | ||
---|---|---|---|---|---|---|---|
HR | 95% CI | HR | |||||
Age | |||||||
≤43 | 28 | Ref. | Ref. | ||||
>43 | 28 | 2.6 | 0.5–13.4 | 0.25 | 2.9 | 0.6–15.2 | .2 |
HCT-CI | |||||||
1–2 | 39 | Ref | |||||
>2 | 17 | 0.9 | 0.2–4.5 | 0.9 | 0.3 | 0.04–2.8 | 0.3 |
Donor type | |||||||
Matched related | 23 | 0.2 | 0.02–1.4 | 0.1 | 0.5 | ||
Matched unrelated | 23 | Ref. | Ref. | 0.8 | |||
Mismatched | 10 | 0.4 | 0.05–3.8 | 0.5 | can’t estimate | ||
Pre-TP LVEF | |||||||
≤35 | 10 | Ref. | Ref. | ||||
36–40 | 21 | 1.6 | 0.2–15.1 | 0.7 | 1.6 | 0.2–16 | 0.7 |
>40 | 25 | 1.3 | 0.1–13 | 0.8 | 1.3 | 0.1–12.5 | 0.8 |
Smoking status | |||||||
Smoker | 20 | 0.7 | 0.1–3.4 | 0.6 | 3.9 | 0.7–20.2 | 0.1 |
Nonsmoker | 36 | Ref. | |||||
Prep regimen | |||||||
Ablative | 21 | 0.7 | 0.1–3.4 | 0.6 | 0.2 | 0.03–2.0 | 0.2 |
Reduced intensity | 35 | Ref. | |||||
Cyclophosphamide in prep regimen | |||||||
Yes | 17 | 0.9 | 0.2–4.7 | 0.9 | 1.6 | 0.3–6.9 | 0.6 |
No | 39 | Ref. | |||||
Diagnosis | |||||||
Acute leukemia | 32 | Ref. | Ref. | ||||
Lymphoma | 16 | 1.5 | 0.2–8.8 | 0.7 | 1.4 | 0.2–8.4 | 0.7 |
Others | 8 | 3 | 0.5–17.9 | 0.2 | 3.5 | 0.5–18.3 |
NRM indicates nonrelapse mortality; HR, hazard ratio; CI, confidence interval; HCT-CI, hematopoietic stem cell transplantation comorbidity index; TP, transplant; Prep regimen, preparative regimen.