Figure 5.

Platelet factor 4 (PF4)–modulated cell cycle and apoptosis-related gene expression. (a) Human bone marrow mesenchymal stem cells were pre-incubated with PF4 or equivalent heated PF4 for 12 h before 500 cGy ionizing irradiation, and gene expression was analysed by quantitative reverse transcription–polymerase chain reaction at 20 h and 4 days after ionizing irradiation (IR). The unradiated cells were used as a control. (b) Schematic diagram of potential signaling triggered by PF4. Bars, means ± standard deviation. *p < 0.05; **p < 0.01, #p < 0.001; n = 8. PCNA, proliferating cell nuclear antigen.