Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Oct 25;63(8):1313–1324. doi: 10.1136/gutjnl-2012-304058

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/3.0/

PMC Copyright notice

Localisation of carboxylester lipase (CEL) in pancreatic acinar cells and lobules. (A) Light-transmitted and fluorescent images of acinar cells showing CEL (green) location in the apical granular region, surrounded by peri-granular mitochondria (mitochondrial peptidyl-prolyl cis-trans isomerase: red). Nuclei co-stained with Hoechst 33342 (blue). (B) Similar distribution of CEL in unstimulated intact tissue. Treatment with physiological cholecystokinin (10 pM for 30 min) caused CEL to redistribute into the lumen between acinar clusters suggestive of secretion. (C) A diffuse intragranular and extragranular (apical and basolateral) distribution of CEL was observed in intact pancreatic lobules obtained from mice treated with ethanol/POA combination to induce alcoholic acute pancreatitis (i.p. ethanol (1.35 g/kg) and POA (150 mg/kg)).