Table 3.

Analysis of visual analogue scale (VAS) pain intensity score (intention-to-treat population): adjusted change from baseline

	Methoxyflurane (N=149)	Placebo (N=149)	Estimated treatment effect (95% CI)	p Value
Adjusted* change from baseline (mm)
Overall	−30.2	−15.2	−15.1 (−19.2 to −11.0)	<0.0001
5 min	−23.1	−11.3	−11.8 (−15.6 to −8.0)
10 min	−28.9	−14.8	−14.1 (−18.4 to −9.8)
15 min	−34.0	−15.5	−18.5 (−23.4 to −13.5)
20 min	−35.0	−19.0	−16 (−21.3 to −10.7)
Time by treatment interaction				0.0019

Pain scores recorded after the start of the planned emergency department procedure were excluded from the analysis. Pain scores taken after initiation of rescue medication were included in the analysis.

*Least squares mean has been adjusted for baseline pain score and age group (adolescent/adult).

N, number of patients.