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. Author manuscript; available in PMC: 2015 Jan 24.
Published in final edited form as: Nat Commun. 2014 Jul 24;5:4467. doi: 10.1038/ncomms5467

Figure 1. The MEP pathway for isoprenoid biosynthesis.

Figure 1

The MEP pathway for the synthesis of isoprenoids is specifically inhibited by FSM. FSM competitively inhibits PfDXR and indirectly inhibits PfIspD8. Abbreviations: DOXP, 1-deoxy-D-xylulose 5-phosphate; MEP, 2-C-methylerythritol 4-phosphate; CDP-ME, 4-diphosphocytidyl-2-C-methylerythritol; CDP-MEP, 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate; MEcPP, 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate; IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; DXR, DOXP reductase; IspD, CDP-ME synthase; IspE, CDP-ME kinase; IspF, MEcPP synthase.