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. Author manuscript; available in PMC: 2015 Jan 24.
Published in final edited form as: Nat Commun. 2014 Jul 24;5:4467. doi: 10.1038/ncomms5467

Figure 9. Model of PfHAD1 function.

Figure 9

PfHAD1 (blue arrows) may dephosphorylate intermediates of glycolysis. Loss of PfHAD1 may increase local levels of sugar phosphates and increase substrate availability to the apicoplast MEP pathway (green). Use of PEP as a substrate is unlikely, given poor PfHAD1 activity against this substrate in vitro (Fig. 6). Green reactions and substrates are part of the MEP pathway. PfiTPT and PfoTPT are transporters responsible for import of PEP and DHAP into the apicoplast56,57. The conversion of PEP and DHAP into pyruvate and gly3P, respectively, are catalyzed by apicoplast-localized pyruvate kinase (PK)58 and triosephosphate isomerase (TPI)59.