. Author manuscript; available in PMC: 2014 Sep 12.

Published in final edited form as: Nat Commun. 2014 Mar 12;5:3459. doi: 10.1038/ncomms4459

Table 1. Chemical structures of modified siRNAs.

Chemical structures of modified siRNAs used for the initial screen. Locations of modification are indicated for each sequence.

	Sense (5’f to 3’f)	Antisense (3’f to 5’f)
UM	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCUAGAUGUAC
PS2-1	UGACAUGCCGAUCUACAU_S2G_S2TT	TTACUGUACGGCUAGAUGUAC
PS2-2	UGA_S2CAUGCCGAU_S2CUACAUGTT	TTACUGUACGGCUAGAUGUAC
PS2-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_S2G_S2CUAGAUGUAC
PS2-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_S2AGAU_S2GUAC
MePS2-1	UGACAUGCCGAUCUACAU_MeS2G_MeS2TT	TTACUGUACGGCUAGAUGUAC
MePS2-2	UGA_MeS2CAUGCCGAU_MeS2CUACAUGTT	TTACUGUACGGCUAGAUGUAC
MePS2-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_MeS2G_MeS2CUAGAUGUAC
MePS2-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_MeS2AGAU_MeS2GUAC
MePS-1	UGACAUGCCGAUCUACAU_MeSG_MeSTT	TTACUGUACGGCUAGAUGUAC
MePS-2	UGA_MeSCAUGCCGAU_MeSCUACAUGTT	TTACUGUACGGCUAGAUGUAC
MePS-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_MeSG_MeSCUAGAUGUAC
MePS-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_MeSAGAU_MeSGUAC
Me-1	UGACAUGCCGAUCUACAU_MeG_MeTT	TTACUGUACGGCUAGAUGUAC
Me-2	UGA_MeCAUGCCGAU_MeCUACAUGTT	TTACUGUACGGCUAGAUGUAC
Me-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_MeG_MeCUAGAUGUAC
Me-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_MeAGAU_MeGUAC
FPS2-1	UGACAUGCCGAUCUACAU_FS2G_FS2TT	TTACUGUACGGCUAGAUGUAC
FPS2-2	UGA_FS2CAUGCCGAU_FS2CUACAUGTT	TTACUGUACGGCUAGAUGUAC
FPS2-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_FS2G_FS2CUAGAUGUAC
FPS2-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_FS2AGAU_FS2GUAC
FPS-1	UGACAUGCCGAUCUACAU_FSG_FSTT	TTACUGUACGGCUAGAUGUAC
FPS-2	UGA_FSCAUGCCGAU_FSCUACAUGTT	TTACUGUACGGCUAGAUGUAC
FPS-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_FSG_FSCUAGAUGUAC
FPS-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_FSAGAU_FSGUAC
F-1	UGACAUGCCGAUCUACAU_FG_FTT	TTACUGUACGGCUAGAUGUAC
F-2	UGA_FCAUGCCGAU_FCUACAUGTT	TTACUGUACGGCUAGAUGUAC
F-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_FG_FCUAGAUGUAC
F-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_FAGAU_FGUAC