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Differences between sarcopenia and cachexia
| Sarcopenia | Cachexia | |
|---|---|---|
| Definition | Muscle mass <2SD of young healthy population, decreased muscle function | Weight loss >5% in 6 months |
| Mechanism | Aging | Pathologic |
| Comorbid condition | +/− | +++ |
| Functional limitation | ++ | +++ |
| Inflammation | − | ++ |
| Fat mass | Increased | Decreased |
| Protein degradation | −/+ | +++ |
| Resting Energy Expenditure | Decreased | Increased |
| Anorexia | + | ++ |
