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. Author manuscript; available in PMC: 2014 Jul 28.
Published in final edited form as: Curr Med Chem. 2013;20(33):4131–4141. doi: 10.2174/09298673113209990248

Fig. (3). 1,25(OH)2D3 deficiency promotes enhanced inflammatory cytokine production and STAT3 phosphorylation.

Fig. (3)

(A) Serum biochemistry results for IL-6 and TNF-α levels in either tumor-transplanted normal or 1,25(OH)2D3-treated 1α(ase)+/+ and 1α(ase)−/− mice. (B) Immunoblotting results of STAT3 phosphorylation levels in transplanted tumors in either normal or 1,25(OH)2D3-treated 1α(ase)+/+ and 1α(ase)−/− mice. (C) p-STAT3 immunohistochemistry staining results of representative tumor slices in either normal or 1α(ase)+/+ and 1α(ase)−/− mice treated with or without 1,25(OH)2D3 (magnification x400). The results are representative of at least 3 independent samples. *p<0.05; **p<0.01; ***p<0.001.