Skip to main content
. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Behav Neurosci. 2013 Dec;127(6):923–931. doi: 10.1037/a0034839

Figure 4. Experiment 3: Local bulbar modulation.

Figure 4

Treatment groups consisted of cannulated males and females given no systemic E2 replacement at time of GDx and receiving bilateral infusions of either saline (Non-Estradiol), E2 (Estradiol), or E2+PHTPP (ERβ antagonist; Estradiol+PHTPP) approximately 40 minutes before behavioral trials. Investigation time significantly reduced between H1 and H4 indicates that surgical and drug treatments did not impair the animals' ability to detect and odor or form an habituation to the odor. A significant difference between H4 and 30m trial indicates that the odor was treated as a novel odor rather than a familiar odor. * indicates a significant difference between a 30 or 60 minute test trial and the last habituation trial. Red arrows highlight the fact the female mice with E2 replacement remembered the odor at 30 minutes.