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Solubility and permeability characteristics of drug substances based on BCS sub-classification.
| BCS sub- classification |
Solubility at pH 2 |
Solubility at pH 6.5 |
Permeability |
|---|---|---|---|
| I | High | High | High |
| IIaa | Low | High | High |
| IIbb | High | Low | High |
| IIcc | Low | Low | High |
| III | High | High | Low |
| IVaa | Low | High | Low |
| IVbb | High | Low | Low |
| IVcc | Low | Low | Low |
With a pKa < 5.
With a pKa > 6.
With no pKa(s) or pKa(s) < 0 or >8.
