Table.

Timing of the Appearance of Pathologic Features in the Mouse Model

Feature	1 Month	2 Months	4 Months	6 Months	9 Months
Cre expression	∗
Sod2 deletion	∗
Oxidative stress	†	∗
Increased lipofuscin			∗
Decreased ERG				∗
Fundus abnormalities				∗
Vascular leakage				∗
Longer OS					∗
Distension of Bruch's membrane			†
RPE hypertrophy			∗
Spongy choroid				∗
RPE atrophy				†
Complement factor 5 deposition					†

OS, outer segments.

* The time at which a specific feature of the model was first detected or was first statistically significant.

† A feature that was detected by some criteria but not others (oxidative stress) or that was detected only in a subset of mice (e.g., RPE atrophy).