Table 3.
Panels of biomarkers used for analysis of specificity and sensitivity, using 10% positive cells and 20% positive cells as cut-off thresholds for positivity
|
10% positive cells as cut-off | ||
|---|---|---|
| Panels | Sensitivity | Specificity |
|
KOC, S100P, Mesothelin, MUC1 |
100% |
40% |
|
KOC, S100P, Mesothelin |
100% |
88% |
|
KOC, Mesothelin |
97% |
87% |
|
KOC, S100P |
98% |
96% |
|
KOC, S100P, Mesothelin* |
100% |
99% |
|
20% positive cells as cut-off | ||
|
Panels |
Sensitivity |
Specificity |
|
KOC, S100P, Mesothelin, MUC1 |
100% |
65% |
|
KOC, S100P, Mesothelin |
99% |
94% |
|
KOC, Mesothelin |
96% |
93% |
|
KOC, S100P |
99% |
99% |
| KOC, S100P, Mesothelin* | 100% | 100% |
Note: *At least 2 biomarkers required to be positive in this panel. In the rest of the panels only one biomarker was required to be positive in a panel.