Table 3. Model Effects.
| Parameter | Category | Chi‐Square | df | F | OR (95% CI) | p |
|---|---|---|---|---|---|---|
| mtDNA haplogroup, overall effect | 15.601 | 5 | 3.120 | 0.008 | ||
| H | 1.57 (0.84–2.96) | |||||
| J | 1.2 (0.55–2.63) | |||||
| T | 1.23 (0.52–2.88) | |||||
| U | 1.14 (0.55–2.39) | |||||
| K | 0.21 (0.07–0.56) | |||||
| Other | 0.83 (0.38–1.82) | |||||
| Age | 132.52 | 1 | 132.52 | 1.04 per year (1.03–1.04) | 0.000 | |
| Motor score of GCS | 46.739 | 6a | 7.790 | 0.000 | ||
| No response | 1 REFERENCE | |||||
| Extending to pain | 1.35 (0.64–2.87) | |||||
| Abnormal flexion | 1.6 (0.73–3.55) | |||||
| Withdrawing to pain | 0.58 (0.34–0.93) | |||||
| Localizing to pain | 0.57 (0.34–0.93) | |||||
| Obeying commands | 0.3 (0.18–0.48) | |||||
| Not assessable | 0.23 (0.09–0.61) | |||||
| CT Marshall grade | 59.238 | 5 | 11.856 | 0.000 | ||
| 6 | 1 REFERENCE | |||||
| 5 | 0.38 (0.22–0.67) | |||||
| 4 | 0.24 (0.03–1.8) | |||||
| 3 | 0.39 (0.19–0.78) | |||||
| 2 | 0.22 (0.13–0.38) | |||||
| 1 | 0.52 (0.27–0.84) | |||||
| Traumatic SAH | 10.149 | 1 | 10.149 | 0.001 | ||
| Absent | 1 REFERENCE | |||||
| Present | 1.57 (1.17–2.11) | |||||
| Hypotension [blood pressure < 90mmHg within the first 24 hours] | 4.002 | 1 | 4.4002 | 0.046 | ||
| Absent | 1 REFERENCE | |||||
| Present | 1.8 (1.2–2.7) | |||||
| Hypoxia [PO2 < 8kPa or SaO2 < 85% in the first 24 hours] | 0.945 | 1 | 0.945 | 0.331 | ||
| No hypoxia | 1 REFERENCE | |||||
| Confirmed hypoxia | 0.67 (0.3–1.5) | |||||
| Pupillary reactivity | 9.112 | 2 | 4.556 | 0.011 | ||
| Both reacting | 1 REFERENCE | |||||
| Only 1 reacting | 1.71 (1.05–2.78) | |||||
| Neither reacting | 1.83 (1.09–3.08) | |||||
| ApoE genotype [ε4 vs ε2 or ε3] | 0.507 | 1 | 0.507 | 0.476 | ||
| ε4 | 1 REFERENCE | |||||
| ε2/ε3 | 0.82 (0.41–1.63) | |||||
| Interaction between mtDNA haplogroup and age | 13.439 | 5 | 2.688 | 0.02 | ||
| Interaction between mtDNA haplogroup and APOE ε4 | 21.35 | 5 | 4.27 | 0.001 |
Effects of predictors of the ordered regression analysis on the collapsed Glasgow Outcome Scale. Chi‐quare, degrees of freedom (df), F statistics, odds ratio (OR), and significance are shown. OR < 1 favors better outcome. As mtDNA haplogroup is a polynomial term, the ORs for this parameter indicate the odds of better outcome for carriers of each haplogroup compared to noncarriers of the same haplogroup.
a
Includes the 6 possible motor scores and the category “not assessable.”
CI = confidence interval; CT = computed tomography; GCS = Glasgow Coma Scale; SAH = subarachnoid hemorrhage.