Table 3.

Dominant and Recessive Models of Log-Linear Analysis of TCblR Variants

	Republic of Ireland				United Kingdom
Variant	Dom RR*	Dom p-value	Rec RR	Rec p-value	Dom RR	Dom p-value	Rec RR	Rec p-value
rs4147651
Case	1.1048	0.4329	0.7598	0.3496	FTC**	FTC	0.6830	0.3386
Mother	1.0342	0.5795	0.5868	0.1055	0.9765	0.5303	1.0637	0.8976
rs7408841
Case	FTC	FTC	1.3588	0.0824	1.2350	0.2127	1.0259	0.9091
Mother	FTC	FTC	0.8482	0.4135	1.1464	0.3378	0.8033	0.3594
rs2232775
Case	FTC	FTC	6.000	0.0086	0.7965	0.4081	FTC	FTC
Mother	FTC	FTC	0.4567	0.3357	0.8394	0.1738	FTC	FTC
rs2927707
Case	1.0561	0.6148	0.7133	0.1091	0.9483	0.7146	0.9659	0.9014
Mother	FTC	FTC	1.2461	0.3263	0.9582	0.6013	0.8331	0.4988
E88del
Case	1.3405	0.7462	FTC	FTC	ND***	ND	ND	ND
Mother	FTC	FTC	FTC	FTC	ND	ND	ND	ND
rs2336573
Case	FTC	FTC	6.5871	0.0037	0.7064	0.2550	FTC	FTC
Mother	FTC	FTC	0.2469	0.1858	0.7518	0.1386	FTC	FTC
rs2227288
Case	1.0210	0.8971	0.6856	0.4932	0.8320	0.3962	0.4258	0.2315
Mother	FTC	FTC	2.6990	0.2006	0.8055	0.5434	0.4428	0.3369
rs250511
Case	0.7980	0.2625	FTC	FTC	ND	ND	ND	ND
Mother	FTC	FTC	FTC	FTC	ND	ND	ND	ND
rs9426
Case	FTC	FTC	6.7127	0.0035	ND	ND	ND	ND
Mother	FTC	FTC	0.2471	0.1656	ND	ND	ND	ND
rsl73665
Case	0.7253	0.1313	FTC	FTC	0.9480	0.8021	0.7332	0.7084
Mother	FTC	FTC	FTC	FTC	FTC	FTC	2.4150	0.4509
rs250508
Case	0.8428	0.1861	1.2416	0.1621	ND	ND	ND	ND
Mother	0.9832	0.6401	0.7748	0.1239	ND	ND	ND	ND

^*RR for the Recessive Model is the risk of disease with 2 copies divided by risk of disease with 0 or 1 copy; RR for the Dominant Model is the risk of disease with 1 or 2 copies divided by risk of disease with 0 copies.

^**FTC = Failure to converge

^***ND = not done

Note: none of the reported p-values are <0.05 upon correction for multiple tests (permutation)