Table 1.
Physiological role of Slack-mediated IKNa in specific neuronal cell types (selected references).
| Neuronal type | Animal/Age | IKNa contribution | Reference |
|---|---|---|---|
| Ciliary and trigeminal ganglia | E7–8, chick or quail embryos | Sodium-dependent outward current | Bader et al. (1985) |
| Layer V neurons of sensorimotor cortex | Cats | sAHP, cellular excitability | Schwindt et al. (1989) |
| Spinal cord neurons | Lamprey (Lampetra fluviatilis) | sAHP, neuronal frequency regulation | Wallen et al. (2007) |
| MNTB principal neurons | P11, 129SV/EMS mice | Accuracy of timing of APs to high-frequency stimulation | Yang et al. (2007) |
| Olfactory bulb tufted/mitral cells, corpus striatum medium spiny neuron (MSN) | P2, rat pups | Delayed outward current | Budelli et al. (2009) |
| Olfactory bulb mitral cells | <1 m, C57BL/6 Kv1.3-/- mice | Compensatory increase in Slack expression in Kv1.3-/- mitral cells, leading to increased delayed outward current | Lu et al. (2010) |
| Peptidergic nociceptors in dorsal root ganglion (DRG) | E15, Sprague-Dawley rat embryos | APD, firing accommodation to stimulus, cellular excitability | Nuwer et al. (2010) |
| Non-peptidergic nociceptors in DRG | <1 m, F344 rats | APD, firing threshold, cellular excitability | Huang et al. (2013) |
| Vestibular afferent neurons (VAN) | <1 m, Sprague-Dawley rats | APD, rate of repolarization, amplitude of AHP, phase locking of APs | Cervantes et al. (2013) |
MNTB, medial nucleus of the tripezoid body; DRG, dorsal root ganglion; E, embryonic; P, post-natal; m, month; sAHP, slow afterhyperpolarization; AP, action potential; APD, action potential duration.