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. 2014 Jul 28;8:201. doi: 10.3389/fncel.2014.00201

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Copyright © 2014 Tomassy and Fossati.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human OPCs and OLs can be differentiated in vitro from pluripotent stem cells. hPSC are shown as NANOG⁺ (green)/TRA-1-60⁺(red); hOPCs as OLIG2⁺(green)/SOX10⁺(red); and hOL as O4⁺ cells (green). Images are based on results in press in Stem Cell Reports (Douvaras et al., 2014). The critical agents that promote oligodendrocyte differentiation have been identified. We showed that bFGF (shown in gray) is dispensable. Future studies will investigate whether the cells generated in the dish constitute one homogenous population or different subtypes. RA: retinoic acid, SHH: sonic hedgehog, bFGF: basic fibroblast growth factor, IGF-1: insulin like growth factor-1, EGF: epidermal growth factor, T3: triiodothyronine, PDGF-AA: platelet derived growth factor, NT3: neurotrophin 3.