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. 2014 Jul 19;14:57. doi: 10.1186/1471-2253-14-57

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Copyright © 2014 Piegeler et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of ropivacaine on acute lung injury. Acute lung injury was induced by either hyperinflation (HTV), bacterial lipopolysaccharide (LPS), or a combination of the two (“double-hit” model) in C57BL/6 wild type (C57 WT) mice. ALI was assessed by measuring (A) Excess lung water (ELW), (B) extravascular plasma equivalents (EVPE), (C) permeability index, and (D) myeloperoxidase activity as described in Methods. Values shown are mean ± SD (n = 7); ^#p < 0.05 vs. control (NS-NS-HTV); *p < 0.05 vs. LPS-NS-HTV.