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. 2014 Jul 19;14:57. doi: 10.1186/1471-2253-14-57

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Copyright © 2014 Piegeler et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of ropivacaine on acute lung injury in ICAM-1^−/−mice. ALI, induced by either hyperinflation (HTV), bacterial lipopolysaccharide (LPS), or a combination of the two (“double-hit” model) in ICAM-1^−/− mice, was assessed by measuring (A) excess lung water (ELW), (B) extravascular plasma equivalents (EVPE), (C) permeability index, and (D) myeloperoxidase activity as described in Methods. Values shown are mean ± SD with n = 7, except for MPO activity (n = 3). ^#p < 0.05 vs. control (NS-NS-HTV); *p < 0.05 vs. LPS-NS-HTV.