Table 4.
Incidence of lung tumors and mesotheliomas in rats following exposure to asbestos samples (from [[65],[66]])
| Inhalation 10 mg/m 3 * | ||
|---|---|---|
| |
Amosite |
|
| |
LAF |
SAF |
| 11% >10 μm |
0.1% > 10 μm |
|
| Number of rats |
40 |
42 |
| Lung tumor |
11 (27.5%) |
0 (0%) |
| Mesothelioma |
3 (7.5%) |
1 (2.4%) |
| |
Chrysotile |
|
| |
LAF |
SAF |
| 2% >10 μm |
0.7% > 10 μm |
|
| 0.1% >30 μm |
0.03% >30 μm |
|
| Number of rats |
40 |
40 |
| Lung tumor |
20 (50%) |
7 (17.5%) |
| Mesothelioma |
3 (7.5%) |
1 (2.4%) |
|
Mesotheliomas after intraperitoneal injection** | ||
| |
Amosite |
|
| |
LAF |
SAF |
| Number of rats |
Not provided |
Not provided |
| 10 mg |
21 (88%) |
0 (0%) |
| 25 mg |
20 (90%) |
1 (4%) |
| |
Chrysotile |
|
| Number of rats |
24 |
24 |
| 2.5 mg |
22 (91.6%) |
8 (33.3%) |
| 25 mg | 23 (95.8%) | 22 (91.6%) |
*Inhalation: 2 lung tumors and no mesothelioma in control rats.
**Intraperitoneal injection: no mesothelioma in control rats.