Table 2.
Results of implementing the DiCE evidence scoring system in four contexts
| Gene and phenotype | Omic/Observational evidence | Biological database evidence | Experimental evidence | Total evidence score* | |
|---|---|---|---|---|---|
| |
Single finding |
Validation |
|
|
|
| Hemoglobin S and malaria resistance (a positive control that would not be detected with traditional methods) |
1 |
2 |
3 |
3 |
9 |
|
ATP2B4 and malaria resistance (new lead) |
1 |
2 |
3 |
3 |
9 |
|
MARVELD3 and malaria resistance (new lead) |
1 |
0 |
0 |
0 |
1 |
| PPARγ and type 2 diabetes (another positive control that would not be detected with traditional methods) | 0 | 0 | 3 | 3 | 6 |
*a total score of 6–10 is considered strong evidence.