Table 2.

Comparison of biomarkers for detection of metastatic colorectal cancer cells

Marker	Stable	Amplifiable	Widely reported	FDA approval	False negative	False positive	Ref.
DNA methylation	●	●			●		[16]
mRNA		●	●			●	[7]
Micro RNA	●	●					[81]
CellSearch (EpCAM)	●			●	●		[39]
Genetic mutation	●	●			●		[15]

EpCAM: Epithelial cell adhesion molecule; FDA: Food and Drug Administration.