Figure 3.

Aβ balance, systemic overview. The main discussion regarding Aβ clearance has been centered at the brain level. Increased production and decreased removal from the brain certainly constitutes a highly relevant issue. The relevance of the BBB integrity or the Aβ excretion through the ChP are now recognized as key elements regarding Aβ brain levels. However, a growing body of evidence suggest the critical role of systemic final excretion of Aβ in AD. In this regard, expression levels of LRP 1 within the liver and hepatocyte are critical for the appropriate liver excretion of Aβ, which could account for up to the 60% of the total systemic Aβ clearance. On the other hand, even when not fully understood, kidneys not only play an important role in systemic Aβ clearance, but the precise renal function might account for blood vessels health and appropriate blood pressure levels which could influence the BBB integrity and its functionality. LRP, low density lipoprotein-related receptor protein; sLRP-Aβ, soluble LRP bond to Aβ; BCSFB, brain-cerebrospinal fluid barrier; ChP, choroid plexus.