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Binge alcohol drinking increases phosphorylation of c-Jun N-terminal kinase (JNK) as shown by (A) immunohistochemistry (image 3 compared to image 1) and (B) Western blot. Livers were collected 18 h after the last ethanol gavage. CBD partially blocked the activation of JNK by binge alcohol. *p < 0.05 comparing ethanol/vehicle to vehicle/vehicle. &p < 0.05 comparing ethanol/CBD to ethanol/vehicle. (C) P38 MAPK phosphorylation is not increased by binge alcohol consumption.
