Table 5.

List of other syndromes where hamartomatous polyps are frequent

	Clinical hallmarks	Gene	Cancer
Gorlin syndrome	Keratocysts of the jaw, hyperkeratosis of palm and soles, basal cell carcinomas, skeleton abnormalities, macrocephaly, frontal bossing	PTCH1	Basal cell carcinomas, medullablastoma
Multiple endocrine neoplasia type 2B	Mucosal neuromas of the lips an tongue, medullated corneal nerve fibers, distinctive facies with enlarged lips and tongue, an asthenic “marfarnoid habitus, and medullary thyroid cancer.	RET	Medullary thyroid cancer, pheochromocytoma
Neurofibromatosis type 1	Café au lait spots, axillary and inguinal freckling, and neurofibromas.	NF1	Optic gliomas, malignant peripherical nerve sheath tumours, breast
Birt-Hogg-Dubé	Skin fibrofolliculomas, spontaneous pneumothorax	FLCN	Renal