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. 2014 Jun 2;13:210. doi: 10.1186/1475-2875-13-210

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Copyright © 2014 Le et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Chemical mechanism of transglutaminase and DHI inhibitors. (A) Mechanism of transglutaminase isopeptide bond formation. (B) Structure of acivicin, S-DHI-derived transglutaminase inhibitors.