Figure 2.

Synthetic routes to generate DHI inhibitor library. (A) Route for synthesis of previously reported DHI inhibitors. (B) Inverted route to utilize commercial BOC derivatives of amino acids. (a) 4-nitrophenyl carbonate, N-methylmorpholine, CH₂Cl₂, RT, overnight; (b) LiOH (1 eq.) MeOH/THF; (c) (S)-DHI, EDCI, HOBt, DMF; (d) TFA.