Figure 9.
DHI inhibitor inactive for two cysteine proteases. Cleavage of (A) Ac-YVAD-pNA by caspase-I, or (B) GST-gp78 fusion protein by TEV, in the presence of TG inhibitors: (i) –ve control (DMSO), (ii) 3 (DHI), (iii) iodoacetamide (IA).
DHI inhibitor inactive for two cysteine proteases. Cleavage of (A) Ac-YVAD-pNA by caspase-I, or (B) GST-gp78 fusion protein by TEV, in the presence of TG inhibitors: (i) –ve control (DMSO), (ii) 3 (DHI), (iii) iodoacetamide (IA).