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. 2014 Jul 17;63(8):2690–2701. doi: 10.2337/db13-1863

Figure 5.

Figure 5

Effects of HFF and aPKC inhibitors ICAP (I) and ACPD (A) on glucose tolerance in fasted mice (A), resting and insulin-stimulated serum glucose levels in fed mice (B), serum insulin levels in fasted and fed mice (C), and serum levels of triglycerides and cholesterol in fed mice (D). Over 10 weeks, mice were consuming low-fat (L) and high-fat (H) diets and treated with or without aPKC inhibitor, as in Fig. 1. At 9 weeks, after an overnight fast, mice were subjected to glucose tolerance testing (2 mg glucose/kg body wt i.p. and measurement of blood glucose at 0, 30, 60, 90, and 120 min). At 10 weeks, 15 min before killing, fed mice were treated with or without insulin (1 unit/kg body wt). Blood and sera were examined for indicated parameters. Values are means ± SEM of 12 determinations in panels A, C, and D (15-min insulin treatment did not alter serum lipid values) and mean ± SEM of 6 determinations in B. *P < 0.05 and ***P < 0.001 for indicated comparisons. HF, high fat; LF, low fat.