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. 2014 Jul 17;63(8):2788–2799. doi: 10.2337/db13-1597

Figure 5.

Figure 5

GLP-1 restores muscle metabolic insulin sensitivity during lipid infusion. Each rat received a systemic infusion of either saline or lipid for 240 min with a euglycemic insulin clamp (3 mU/kg/min) superimposed in the last 3 h and either saline or GLP-1 (30 pmol/kg/min) for the last 2 h. A: Time course of GIR (n = 10–15/group). B: GIR AUC from 60–180 min; compared with insulin alone, *P < 0.05. C: Muscle insulin uptake; n = 5–11 each. Compared with saline or Intralipid group, *P < 0.05. D: Muscle Akt phosphorylation; compared with Intralipid + insulin, *P < 0.01. E: Muscle eNOS phosphorylation. F: Muscle ERK1/2 phosphorylation. G: Aorta PKA phosphorylation; compared with Intralipid + insulin, *P < 0.01. n = 4–8/group for D–G. P, phosphorylated; T, total.