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HFD feeding abolishes insulin-mediated but not GLP-1 + insulin–mediated muscle microvascular perfusion. Each rat was fed an LFD or HFD for 4 weeks. A: Infusion protocol. B: MBV. C: MFV. D: MBF; n = 9 to 10/group. E: Muscle oxygen saturation; n = 4–8/group. F: Plasma NO levels; n = 4–8/group. Compared with respective baseline (0 min), *P < 0.05; compared with HFD + Insulin, @P < 0.05. VI, video intensity.
