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. 2014 Jul 17;63(8):2702–2713. doi: 10.2337/db14-0276

Figure 2.

Figure 2

Effect of maternal and postweaning HF diet on juvenile offspring hepatic lipid accumulation and lipogenic capacity. A: Liver triglyceride concentrations measured in offspring from CON, HF+IS, and HF+IR mothers (horizontal axis labels) on the postweaning CON (white bars) or HF (black bars) diet. In panels A and C, when the main effect of maternal group was significant, comparisons between groups are indicated: *P < 0.05 vs. maternal CON and **P < 0.05 vs. maternal HF+IS. B: Histological analysis of livers stained with hematoxylin and eosin. C: Hepatic mRNA expression of lipid metabolism genes (n = 21, 9, 5, 5, 9, and 16 per group). The main effect of postweaning CON versus HF diet is shown as #P < 0.05. D: Primary hepatocytes were treated for 8 h with high glucose and lipogenic hormones (insulin and dexamethasone). Gene expression results are expressed as fold increase relative to basal treatment (n = 2 CON/CON in white bars, 3 HF+IR/CON in black bars). *P < 0.05 vs. CON/CON; #P < 0.10 vs. CON/CON.