Figure 5.

Kinetic modeling of histone methylation dynamics. (A). Logarithmic function that fits a generic fully labeled monomethylated peptide. A = the final methyl labeling efficiency of the peptide; B = time constant. (B). Set of first order differential equations that fits a generic unmodified histone peptide with the respective unlabeled and labeled monomethylated peptides. α = rate of synthesis; k_0→1 = monomethylation with light SAM; k′_0→1 = monomethylation with heavy SAM; k_1→0 = demethylation from the monomethylation state; t₀ = degradation of unmodified state; t₁ = degradation of monomethylated state.