Table 1.
Maternal demographic and clinical measures
| Exposure during pregnancy | P values | |||||||
|---|---|---|---|---|---|---|---|---|
| Measure | All (N=174) |
None (N=97) |
SSRI (N=46) |
MDD (N=31) |
Overall | SSRI v None |
MDD v None |
MDD v SSRI |
| Age | 30.5 ± 5.7 | 30.6 ± 5.4 | 31.3 ± 5.1 | 28.7 ± 7.0 | 0.126 | |||
| Race | 0.004 | 0.353 | 0.012* | 0.002* | ||||
| White | 141 (81.0) | 81 (83.5) | 42 (91.3) | 18 (58.1) | ||||
| Black | 28 (16.1) | 14 (14.4) | 3 (6.5) | 11 (35.5) | ||||
| Other | 5 (2.9) | 2 (2.1) | 1 (2.2) | 2 (6.5) | ||||
| White race | 141 (81.0) | 81 (83.5) | 42 (91.3) | 18 (58.1) | <.001 | 0.209 | 0.003* | <.001* |
| Education | 0.002 | 0.842 | <.001* | 0.012* | ||||
| <High school | 10 (5.7) | 3 (3.1) | 2 (4.3) | 5 (16.1) | ||||
| High school | 15 (8.6) | 7 (7.2) | 3 (6.5) | 5 (16.1) | ||||
| Some college | 30 (17.2) | 11 (11.3) | 8 (17.4) | 11 (35.5) | ||||
| College | 72 (41.4) | 45 (46.4) | 20 (43.5) | 7 (22.6) | ||||
| Graduate school | 47 (27.0) | 31 (32.0) | 13 (28.3) | 3 (9.7) | ||||
| College degree | 119 (68.4) | 76 (78.4) | 33 (71.7) | 10 (32.3) | <.001 | 0.386 | <.001* | <.001* |
| Employed | 103 (59.5) | 68 (70.1) | 21 (46.7) | 14 (45.2) | 0.006 | 0.007* | 0.012* | 0.897 |
| Marital status | 0.053 | |||||||
| Single | 38 (21.8) | 17 (17.5) | 8 (17.4) | 13 (41.9) | ||||
| Married/cohabiting | 131 (75.3) | 77 (79.4) | 36 (78.3) | 18 (58.1) | ||||
| Divorced/separated | 5 (2.9) | 3 (3.1) | 2 (4.3) | 0 (0.0) | ||||
| Widowed | 5 (2.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
| Married/cohabiting | 131 (75.3) | 77 (79.4) | 36 (78.3) | 18 (58.1) | 0.049 | 0.878 | 0.018 | 0.058 |
| Pre-pregnancy BMI | 26.4 ± 7.0 | 25.0 ± 5.6 | 27.3 ± 6.0 | 29.3 ± 10.5 | 0.016 | 0.008* | 0.062 | 0.979 |
| Parity | 1.9 ± 0.95 | 1.7 ± 0.81 | 2.1 ± 0.95 | 2.2 ± 1.2 | 0.016 | 0.017 | 0.025 | 0.823 |
| Parity | 0.087 | |||||||
| 1 | 74 (42.5) | 49 (50.5) | 15 (32.6) | 10 (32.3) | ||||
| 2 | 61 (35.1) | 33 (34.0) | 17 (37.0) | 11 (35.5) | ||||
| 3+ | 39 (22.4) | 15 (15.5) | 14 (30.4) | 10 (32.3) | ||||
| Smoked tobacco during pregnancy | 17 (9.8) | 8 (8.2) | 5 (10.9) | 4 (12.9) | 0.718 | |||
| Drank alcohol during pregnancy | 0.061 | |||||||
| No | 119 (68.4) | 67 (69.1) | 30 (65.2) | 22 (71.0) | ||||
| Once a week or less | 42 (24.1) | 27 (27.8) | 11 (23.9) | 4 (12.9) | ||||
| More than once a week | 13 (7.5) | 3 (3.1) | 5 (10.9) | 5 (16.1) | ||||
| Anxiety (lifetime) | 57 (32.8) | 23 (23.7) | 21 (45.7) | 13 (41.9) | 0.016 | 0.008* | 0.049 | 0.747 |
| Baseline SIGH-ADS29 | 11.8 ± 7.1 | 8.2 ± 4.8 | 15.5 ± 7.1 | 17.6 ± 7.0 | <.001 | <.001* | <.001* | 0.208 |
Abbreviations BMI body mass index; SIGH-ADS Structured interview guide for the Hamilton rating scale for depression with atypical depression supplement.
*
Significant after Bonferroni correction.