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. 2014 Apr 27;9:14. doi: 10.1186/1750-1326-9-14

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Copyright © 2014 Sharma et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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mRNA expression patterns of selected optic nerve genes following ONC insult. Pooled microarray mRNA expression changes were validated in individual samples by qRT-PCR. Relative fold change in each sample was determined based on a 2 fold exponential using mRNA expression values normalized to Gapdh and the contralateral control eye. Fold values of each gene presented as mean ± SEM. (A) Neuritin 1 (Nrn1), (B) Synaptotagmin 1 (Syt1) and (C) Synaptoporin (Synpr). Statistical significance for each time-point determined by one-way ANOVA -Tukey post hoc test, * p < 0.05, ** p < 0.01, *** p < 0.001, n = 5.