Table 3.
Number of validated mRNA targets of miRNAs that were differentially up- or down-regulated by SNL nerve injury
| miRNA identifier | RPM mean HA + LA (sham) | diff-reg abs. value, by subtraction | No. of verified mRNA targets | Target genes relevant to pain physiology |
|---|---|---|---|---|
|
Differentially regulated miRNA | ||||
| rno-miR-378b |
49.4 |
0.457 |
0 |
|
| rno-miR-322-3p |
30.1 |
0.494 |
2 |
- |
|
rno-miR-30d-5p |
10,117 |
0.132 |
5 |
Bdnf |
| rno-miR-493-3p |
73.1 |
0.316 |
0 |
|
| rno-miR-1839-5p |
110.9 |
0,278 |
0 |
|
|
rno-miR-125b-5p |
3147.6 |
0.265 |
45 |
Tnf, Stat3 |
| rno-miR-369-3p |
12.8 |
0.189 |
0 |
|
| rno-let-7f-2-3p |
9.9 |
0.567 |
0 |
|
| rno-miR-340-3p |
10.2 |
0.561 |
1 |
- |
| rno-miR-6331 |
12.8 |
0.467 |
0 |
|
| rno-miR-379-5p |
194.7 |
0.278 |
0 |
|
|
Canonical miRNA of unique sequence isomiR (
diff-reg
of isomiR) | ||||
| rno-miR-101a-3p |
1735.9 |
0.079 |
28 |
- |
| rno-miR-130a-3p |
470.8 |
0.160 |
16 |
Tac1 |
|
Differential expression at baseline (HA_sham vs. LA_sham) all pools | ||||
| rno-miR-184 |
25.2 |
0.550 |
4 |
- |
| rno-miR-6325 | 16.4 | 0.114 | 0 | |